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Once your system is shut down, press the power button to turn on the system. Then, press Enter to shut down your system. Use the arrow keys to select the Shut down button. Then, hit Enter to see the power options. Then, press the down arrow key to select the Power button. Press Tab until you select the bottom left options. Press Ctrl + Esc to open the Start Menu Window. Therefore, try restarting the computer or a laptop by following the steps. Hence, the USB mouse stopped working suddenly. The best way to start troubleshooting the USB mouse is to restart your computer because it could be possible that the USB ports are not able to receive power from the motherboard. This article is fully compatible with the keyboard, which means you don’t need a mouse to apply the following methods. Besides the corrupted mouse driver, and misconfiguration of USB port power management settings can also lead you to this issue.
Mainly, the issue occurs when a USB port you used to plug the mouse stops working.
If your USB mouse stops working suddenly, there are various reasons behind it, including hardware and software.